The Nationwide Relay Leadership Team is a group of leadership volunteers who work alongside American Cancer Society staff to develop strategy to and directly support Relay For Life events across the country.

Regional Relay For Life Leads work to represent the needs of their region, and provide support for Relay For Life on their Community Fundraising Leadership Team (CFLT). The NRLT is also a part of the larger Nationwide Community Fundraising Leadership Team, which is made up of volunteers representing all Community Fundraising events and initiatives at the American Cancer Society.